| First Author | Haub O | Year | 1991 |
| Journal | Development | Volume | 112 |
| Issue | 2 | Pages | 397-406 |
| PubMed ID | 1794310 | Mgi Jnum | J:458 |
| Mgi Id | MGI:48995 | Doi | 10.1242/dev.112.2.397 |
| Citation | Haub O, et al. (1991) Expression of the fibroblast growth factor-5 gene in the mouse embryo. Development 112(2):397-406 |
| abstractText | Fibroblast growth factors (FGFs) are structurally related mitogens that can regulate the differentiation of a wide variety of cells. As a step towards elucidating the developmental roles played by one of these factors, we have used in situ hybridization methods to examine expression of the murine F gf-5 gene during embryogenesis. F gf-5 RNA was detected at seven distinct sites in the developing mouse embryo: (1) postimplantation epiblast (embryonic day 5 1/4-7 1/2), (2) lateral splanchnic mesoderm (E9 1/2-10 1/2), (3) lateral somatic mesoderm (E10 1/2-12 1/2), (4) myotomes (E10 1/2-12 1/2), (5) mastication muscle (E11 1/2-14 1/2), (6) limb mesenchyme (E12 1/2-14 1/2), and (7) acoustic ganglion (E12 1/2-14 1/2). At several of these sites, expression is spatially restricted within the tissues. We offer several hypotheses regarding the roles of FGF-5 in murine development. |
