|  Help  |  About  |  Contact Us

Publication : Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate.

First Author  Freire AG Year  2017
Journal  Stem Cell Reports Volume  9
Issue  1 Pages  136-148
PubMed ID  28648899 Mgi Jnum  J:316299
Mgi Id  MGI:6835460 Doi  10.1016/j.stemcr.2017.05.025
Citation  Freire AG, et al. (2017) Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. Stem Cell Reports 9(1):136-148
abstractText  Notch signaling plays a role in specifying a cardiac fate but the downstream effectors remain unknown. In this study we implicate the Notch downstream effector HES5 in cardiogenesis. We show transient Hes5 expression in early mesoderm of gastrulating embryos and demonstrate, by loss and gain-of-function experiments in mouse embryonic stem cells, that HES5 favors cardiac over primitive erythroid fate. Hes5 overexpression promotes upregulation of the cardiac gene Isl1, while the hematopoietic regulator Scl is downregulated. Moreover, whereas a pulse of Hes5 instructs cardiac commitment, sustained expression after lineage specification impairs progression of differentiation to contracting cardiomyocytes. These findings establish a role for HES5 in cardiogenesis and provide insights into the early cardiac molecular network.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

2 Bio Entities

Trail: Publication

29 Expression

Trail: Publication