Primary Identifier | MGI:103006 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 226352 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables protein domain specific binding activity. Involved in epithelial to mesenchymal transition. Acts upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Located in focal adhesion and ruffle membrane. Is expressed in several structures, including foregut; lung; metanephros; neural tube; and primitive streak. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). PHENOTYPE: Mice homozygous for a number of different mutations exhibit prenatal lethality and mesodermal and epithelial-mesenchymal transition defects during gastrulation. [provided by MGI curators] |