First Author | Deininger MH | Year | 2002 |
Journal | FEBS Lett | Volume | 514 |
Issue | 2-3 | Pages | 115-21 |
PubMed ID | 11943136 | Mgi Jnum | J:76014 |
Mgi Id | MGI:2178211 | Doi | 10.1016/s0014-5793(02)02430-4 |
Citation | Deininger MH, et al. (2002) The allograft inflammatory factor-1 family of proteins. FEBS Lett 514(2-3):115-21 |
abstractText | The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma-inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins are probably identical with AIF-1 termed Iba1 (ionized Ca(2+)-binding adapter), MRF-1 (microglia response factor) and daintain. Considerable but not complete sequence identity with AIF-1 has been described for IRT-1 (interferon-responsive transcript), BART-1 (balloon angioplasty-responsive transcript), and other, yet unassigned alternatively spliced variants. In this review, genomic and functional characteristics of AIF-1-related proteins are summarized and a common nomenclature is proposed. |