| First Author | Hoyler T | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 4 | Pages | 634-48 |
| PubMed ID | 23063333 | Mgi Jnum | J:188553 |
| Mgi Id | MGI:5441104 | Doi | 10.1016/j.immuni.2012.06.020 |
| Citation | Hoyler T, et al. (2012) The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells. Immunity 37(4):634-48 |
| abstractText | Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13, are required for immune defense against helminth infections, and are involved in the pathogenesis of airway hyperreactivity. Here, we have investigated the role of the transcription factor GATA-3 for ILC2 differentiation and maintenance. We showed that ILC2s and their lineage-specified bone marrow precursors (ILC2Ps), as identified here, were characterized by continuous high expression of GATA-3. Analysis of mice with temporary deletion of GATA-3 in all ILCs showed that GATA-3 was required for the differentiation and maintenance of ILC2s but not for RORgammat(+) ILCs. Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates. |
