| Primary Identifier | MGI:1859648 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 54632 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable S-adenosyl-L-methionine binding activity; tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity; and tRNA 2'-O-methyltransferase activity. Predicted to be involved in cytoplasmic translation; neurogenesis; and wobble position ribose methylation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in ovary; oviduct; and uterus. Used to study non-syndromic X-linked intellectual disability 9. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). PHENOTYPE: Males hemizygous for a null allele exhibit immature synaptic morphology and aberrant synaptic plasticity, impaired fear memory retrieval, impaired spatial learning and increased anxiety-like behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
