| First Author | Fukuda T | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 353 |
| Issue | 1 | Pages | 147-51 |
| PubMed ID | 17174939 | Mgi Jnum | J:117241 |
| Mgi Id | MGI:3695852 | Doi | 10.1016/j.bbrc.2006.12.011 |
| Citation | Fukuda T, et al. (2007) FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1. Biochem Biophys Res Commun 353(1):147-51 |
| abstractText | Fibroblast growth factor 23 (FGF23) is a key humoral factor in phosphate homeostasis and skeletogenesis, though the nature of its intracellular signaling is still unclear. Recently, Egr-1, a zinc-finger transcription factor, was identified as an immediate early response gene of FGF23 in the kidney. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1. Both isoforms of NAB2 induced by FGF23 were localized in the nucleus and suppressed the transcriptional activity of Egr-1. A negative feedback loop established by Egr-1 and NAB2 may thus be involved in mediating the physiological effects of FGF23. |
