| First Author | Umetani M | Year | 2014 |
| Journal | Cell Metab | Volume | 20 |
| Issue | 1 | Pages | 172-82 |
| PubMed ID | 24954418 | Mgi Jnum | J:215482 |
| Mgi Id | MGI:5605435 | Doi | 10.1016/j.cmet.2014.05.013 |
| Citation | Umetani M, et al. (2014) The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab 20(1):172-82 |
| abstractText | Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant oxysterol metabolized by CYP7B1. How 27HC impacts vascular health is unknown. We show that elevations in 27HC via cyp7b1 deletion promote atherosclerosis in apoe(-/-) mice without altering lipid status; furthermore, estrogen-related atheroprotection is attenuated. In wild-type mice, leukocyte-endothelial cell adhesion is increased by 27HC via estrogen receptor (ER)-dependent processes. In monocytes/macrophages, 27HC upregulates proinflammatory genes and increases adhesion via ERalpha. In endothelial cells, 27HC is also proadhesive via ERalpha, and in contrast to estrogen, which blunts NF-kappaB activation, 27HC stimulates NF-kappaB activation via Erk1,2 and JNK-dependent IkappaBalpha degradation. Whereas 27HC administration to apoe(-/-) mice increases atherosclerosis, apoe(-/-);eralpha(-/-) are unaffected. Thus, 27HC promotes atherosclerosis via proinflammatory processes mediated by ERalpha, and it attenuates estrogen-related atheroprotection. Strategies to lower 27HC may complement approaches targeting cholesterol to prevent vascular disease. |
