| Primary Identifier | MGI:1337995 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 224023 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Predicted to enable 14-3-3 protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including centrosome; intercellular bridge; and intracellular membrane-bounded organelle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol; mitotic spindle; and polar microtubule. Predicted to colocalize with lysosome and nucleus. Orthologous to human KLHL22 (kelch like family member 22). PHENOTYPE: Mice homozygous for a null allele exhibit increased growth of implanted tumor cells with reduced survival and Cd4+ and CD8+ T cells expressing IFNgamma, TNF, and granzyme B. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
