| First Author | Malde P | Year | 1994 |
| Journal | Int Immunol | Volume | 6 |
| Issue | 8 | Pages | 1169-76 |
| PubMed ID | 7981146 | Mgi Jnum | J:20384 |
| Mgi Id | MGI:68478 | Doi | 10.1093/intimm/6.8.1169 |
| Citation | Malde P, et al. (1994) Disregulation of Myc expression in murine bone marrow cells results in an inability to proliferate in sub-optimal growth factor and an increased sensitivity to DNA damage. Int Immunol 6(8):1169-76 |
| abstractText | Derivatives of the murine bone marrow-derived, IL-3-dependent cell line, BAF3, were isolated following recombinant retroviral infection which showed disregulated expression of human c-Myc oncoprotein. Such cells entered apoptosis and lost viability more rapidly than parental BAF3 cells when IL-3 was removed. c-Myc disregulation also resulted in an inability of BAF3 cells to survive in either sub-optimal concentrations of IL-3, or saturating concentrations of IL-4 and insulin-like growth factor-1. Furthermore, BAF3 cells with disregulated c-Myc expression were more sensitive to the induction of apoptosis by DNA-damaging agents. These effects of c-Myc disregulation could be inhibited by co-expression of the Bcl-2 oncoprotein. The implications of these data for the transformation of haematopoietic cells by disregulation of Myc expression are discussed. |
