| First Author | Mascrez B | Year | 2004 |
| Journal | EMBO Rep | Volume | 5 |
| Issue | 3 | Pages | 285-90 |
| PubMed ID | 14993927 | Mgi Jnum | J:101966 |
| Mgi Id | MGI:3605970 | Doi | 10.1038/sj.embor.7400094 |
| Citation | Mascrez B, et al. (2004) Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep 5(3):285-90 |
| abstractText | We show that mice expressing retinoid X receptor beta (RXRbeta) impaired in its transcriptional activation function AF-2 (Rxrb(af20) mutation) do not display the spermatid release defects observed in RXRbeta-null mutants, indicating that the role of RXRbeta in spermatid release is ligand-independent. In contrast, like RXRbeta-null mutants, Rxrb(af20) mice accumulate cholesteryl esters in Sertoli cells (SCs) due to reduced ABCA1 transporter-mediated cholesterol efflux. We provide genetic and molecular evidence that cholesterol homeostasis in SCs does not require PPARalpha and beta, but depends upon the TIF2 coactivator and RXRbeta/LXRbeta heterodimers, in which RXRbeta AF-2 is transcriptionally active. Our results also indicate that RXRbeta may be activated by a ligand distinct from 9-cis retinoic acid. |
