| First Author | Cullen PK | Year | 2014 |
| Journal | Learn Mem | Volume | 21 |
| Issue | 4 | Pages | 180-4 |
| PubMed ID | 24634352 | Mgi Jnum | J:312070 |
| Mgi Id | MGI:6782808 | Doi | 10.1101/lm.032961.113 |
| Citation | Cullen PK, et al. (2014) GABA-mediated presynaptic inhibition is required for precision of long-term memory. Learn Mem 21(4):180-4 |
| abstractText | Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a rapid time-dependent decline in memory precision in GABAB(1a) receptor knockout mice. First, we show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory. We then demonstrate that GABAB(1a) receptors are required for the maintenance, but not encoding, of spatial memories. Our findings suggest that GABA-mediated presynaptic inhibition regulates the maintenance of memory precision as a function of memory age. |
