Primary Identifier | MGI:3851821 | Allele Type | Targeted |
Attribute String | Humanized sequence, Hypomorph | Gene | Atr |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A transition mutation in exon 9 replaces a G with an A. This mutation replicates one identified in human patients with Seckel syndrome 1 that disrupts splicing. An frt flanked neo cassette was inserted upstream of exon 8 that was removed by germ line, flp mediated recombination. Western blot analysis confirmed normal protein expression. |