| Primary Identifier | MGI:6144026 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(ALB-PCSK9)APfzr |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgenic construct contains a composite human albumin (ALB) promoter, containing a 235 bp SV40 enhancer element and a 213 bp albumin promoter element, directing expression of human proprotein convertase subtilisin/kexin type 9 (PCSK9) cDNA, followed by a C-terminal V5 tag. A chimeric intron (from pRL-SV40) was inserted between the promoter and PCSK9 cDNA to enhance expression. The transgene expresses primarily in the kidney. |
