| Primary Identifier | IPR039275 | Type | Family |
| Short Name | PDZD8 |
| description | PDZ domain-containing protein 8 (PDZD8) is a molecular tether, connecting endoplasmic reticulum (ER) and mitochondria membranes. This tethering is required for transfer of Ca2+ions between the ER and mitochondrion, which is particularly important in neurones []. PDZD8 is a membrane protein containing a single transmembrane region and contains SMP-LTD (synaptotagmin-like mitochondrial-lipid binding protein) []and PDZ domains and a phorbol-ester/DAG-type zinc finger. Homologues are found in metazoa. |
