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Publication : Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice.

First Author  Le Roy I Year  1999
Journal  C R Acad Sci III Volume  322
Issue  10 Pages  831-6
PubMed ID  10609087 Mgi Jnum  J:68419
Mgi Id  MGI:1932680 Doi  10.1016/s0764-4469(00)86647-0
Citation  Le Roy I, et al. (1999) Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice. C R Acad Sci III 322(10):831-6
abstractText  Genes implicated in consumption of a bitter compound, sucrose octaacetate (SOA), were investigated using a full genomic scanning strategy. For a 0.1 mM concentration, two QTL reached 5.8 and 6.5 lod scores on chromosomes 2 (77 cM) and 11 (14 cM), respectively. For a 1 mM concentration, the Soa linkage on chromosome 6 (58 cM, lod score 9.4) was replicated, and another QTL was found on chromosome 19 (15 cM, lod score 3.2). Candidacy of previously identified genes in the close vicinity of the peak of the QTL was examined.
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