| Primary Identifier | MGI:2445445 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(GFAP-lacZ-TAg121)92Tvd |
| Strain of Origin | (C57BL/6 x DBA/2)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene consists of a human GFAP promoter, an intervening floxed lacZ cassette, and a mutant SV40 T antigen sequence. The 2.2 kb fragment of human GFAP was used to direct transgene expression in central nervous system cells of the astrocyte lineage.The SV40 sequence contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. Immunohistochemical staining of brain sections from transgenic animals showed expression of lacZ and not SV40 T121, as expected. |
