| First Author | Huang S | Year | 1993 |
| Journal | Science | Volume | 259 |
| Issue | 5102 | Pages | 1742-5 |
| PubMed ID | 8456301 | Mgi Jnum | J:63815 |
| Mgi Id | MGI:1861744 | Doi | 10.1126/science.8456301 |
| Citation | Huang S, et al. (1993) Immune response in mice that lack the interferon-gamma receptor [see comments]. Science 259(5102):1742-5 |
| abstractText | Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor. |
