| First Author | Hamano H | Year | 1993 |
| Journal | Eur J Immunol | Volume | 23 |
| Issue | 10 | Pages | 2387-91 |
| PubMed ID | 8405038 | Mgi Jnum | J:15291 |
| Mgi Id | MGI:63418 | Doi | 10.1002/eji.1830231002 |
| Citation | Hamano H, et al. (1993) Expressions of cytokine genes during development of autoimmune sialadenitis in MRL/lpr mice. Eur J Immunol 23(10):2387-91 |
| abstractText | Local cytokine gene expression in vivo was analyzed by direct analysis of RNA obtained from salivary gland tissues of MRL/lpr mice with autoimmune sialadenitis. The expression of cytokine genes were assessed by the reverse-transcriptase polymerase chain reaction, and by immunohistochemical analysis. The expression of interleukin-1(IL-1)beta and tumor necrosis factor was detected before the onset of inflammatory lesions in the salivary glands of mice of 1 or 2 months of age, and IL-6 mRNA expression was clearly detected at the time of onset of typical autoimmune sialadenitis at 3 months of age in MRL/lpr mice, and was up-regulated with advancing age. These results suggest that the overexpression of these inflammatory cytokine genes is involved in the development and progression of organ-localized autoimmunity in the salivary glands of MRL/lpr mice. |
