| First Author | Zhang Y | Year | 2017 |
| Journal | J Invest Dermatol | Volume | 137 |
| Issue | 12 | Pages | 2532-2543 |
| PubMed ID | 28844943 | Mgi Jnum | J:252974 |
| Mgi Id | MGI:6094801 | Doi | 10.1016/j.jid.2017.07.843 |
| Citation | Zhang Y, et al. (2017) The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5(+)CD1d(hi)FcgammaRIIb(hi) Regulatory B-Cell Subset in Lupus. J Invest Dermatol 137(12):2532-2543 |
| abstractText | IL-35 is a critical immunosuppressive cytokine that plays an important role in various autoimmune diseases. The purpose of this study was to determine whether BAFF, a key pathogenic factor in systemic lupus erythematosus, also a dichotomous regulator for B-cell immune responses, has an effect on IL-35-producing regulatory B cells and their underlying mechanisms in lupus. We found that exogenous BAFF could induce IL-35 production by splenic B cells from MRL-Fas(lpr/lpr) mice. BAFF-induced IL-35-producing B cells were mainly from the marginal zone B-cell subset and exhibited a CD5(+)CD1d(hi)FcgammaRIIb(hi) phenotype. These IL-35-producing regulatory B-cell subsets exhibited regulatory effects on both CD4(+)CD25(-) T cells and CD4(+)CD25(+) regulatory T cells. We further identified that BAFF-TACI interaction could induce the production of IL-35 through the classical NF-kappaB1 pathway. In vivo study also showed that BAFF could facilitate IL-35 secretion in marginal zone B cells, whereas anti-BAFF treatment could decrease the frequency of IL-35-producing CD5(+)CD1d(hi)FcgammaRIIb(hi) B cells in MRL-Fas(lpr/lpr) mice. We showed that BAFF could induce IL-35 production by a unique CD5(+)CD1d(hi)FcgammaRIIb(hi) regulatory B-cell subset mainly through TACI activation in lupus, providing an advanced understanding of the regulatory effect of BAFF in autoimmune diseases. |
