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Comment :

Type  MGI:General Description  mutants fed a doxycycline diet to suppress transgene expression from E0.5 until P21 and then switched to a regular diet to induce transgene expression exhibit impaired contextual fear memory at 8 months of age; mutants further treated with doxycycline at 9 months show improved memory function normal chow-fed mutants at 12 months of age show impaired contextual fear memory