| First Author | Aguezzoul M | Year | 2003 |
| Journal | Genomics | Volume | 81 |
| Issue | 6 | Pages | 623-7 |
| PubMed ID | 12782132 | Mgi Jnum | J:83808 |
| Mgi Id | MGI:2663585 | Doi | 10.1016/s0888-7543(03)00053-3 |
| Citation | Aguezzoul M, et al. (2003) Overlap of promoter and coding sequences in the mouse STOP gene (Mtap6). Genomics 81(6):623-7 |
| abstractText | The microtubule-associated proteins STOP are essential for synaptic plasticity and integrated brain function. The STOP gene (Mtap6) is composed of 4 exons and presents different developmental and tissue specific alternative transcripts resulting in the neuronal isoforms E- and N-STOP, and in the fibroblastic F-STOP isoform. We now characterize the transcription initiation sites for neuronal and non neuronal STOP transcripts. Our results show that there is a single neuronal specific promoter for transcription of E- and N-STOP mRNAs. F-STOP mRNA transcription is regulated by a distinct promoter. A remarkable feature of this promoter is that it lies within coding sequences expressed in neuronal E- and N-STOP isoforms. |
