| Primary Identifier | IPR007882 | Type | Family |
| Short Name | MAP6 |
| description | Microtubule-associated protein6 (MAP6) is a calmodulin binding protein that is involved in microtubule stabilisation []. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. MAP6 is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity []. It regulates axonal growth during neuron polarization, which is controlled by a palmitoylation cycle []. MAP6 interacts with TMEM106B, and this interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport []. TMEM106B is a major risk factor for frontotemporal lobar degeneration with TDP-43 pathology. |
