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Allele : Tyr<em1Utr> tyrosinase; endonuclease-mediated mutation 1, University of Tsukuba Laboratory Animal Resource Center
Primary Identifier  MGI:5582799 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Tyr
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  This allele carries a 5-NT deletion (c.230_234delGTGAG:p.Arg77Leufs*8) and is an unintended byproduct from an experiment that targeted arginine codon 77 (CGT) in exon 1 for change to leucine (CTT) (c.230G>T:p.R77L) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This allele was derived from mouse founder line #1 which also carries the desired Tyrem2Utr allele in trans.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • Tyr<delGTGAG291-295>,
  • Tyr<delGTGAG291-295>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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