| First Author | Rodriguez-Sosa M | Year | 2001 |
| Journal | Immunol Cell Biol | Volume | 79 |
| Issue | 4 | Pages | 320-2 |
| PubMed ID | 11488977 | Mgi Jnum | J:110418 |
| Mgi Id | MGI:3640212 | Doi | 10.1046/j.1440-1711.2001.01014.x |
| Citation | Rodriguez-Sosa M, et al. (2001) Susceptibility to Leishmania mexicana infection is due to the inability to produce IL-12 rather than lack of IL-12 responsiveness. Immunol Cell Biol 79(4):320-2 |
| abstractText | Almost all inbred mice are highly susceptible to parasites of the Leishmania mexicana complex that includes L. amazonensis and L. mexicana. Recent studies have reported that T cells from L. amazonensis-infected mice fail to respond to IL-12 due to impaired IL-12R expression. Here, we demonstrate that lymph node cells from L. mexicana-infected C57BL/6 and 129Sv/Ev mice respond efficiently to exogenous IL-12 in vitro and produce IFN-gamma. Moreover, we also show that deletion of signal transducer and activator of transcription (STAT)4 gene in resistant STAT6-/- mice renders them susceptible to L. mexicana. These findings indicate that an inability to produce IL-12 rather than unresponsiveness to this cytokine is responsible for susceptibility to L. mexicana. Moreover, the data also demonstrate that the STAT4-mediated pathway is critical for the development of protective immunity against cutaneous leishmaniasis, regardless of the species of Leishmania and/or genetic background of the mice. |
