| First Author | Kitsukawa T | Year | 1997 |
| Journal | Neuron | Volume | 19 |
| Issue | 5 | Pages | 995-1005 |
| PubMed ID | 9390514 | Mgi Jnum | J:44328 |
| Mgi Id | MGI:1099903 | Doi | 10.1016/s0896-6273(00)80392-x |
| Citation | Kitsukawa T, et al. (1997) Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 19(5):995-1005 |
| abstractText | Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents. |
