| First Author | Johansson MH | Year | 2000 |
| Journal | Eur J Immunol | Volume | 30 |
| Issue | 2 | Pages | 525-33 |
| PubMed ID | 10671208 | Mgi Jnum | J:60377 |
| Mgi Id | MGI:1353223 | Doi | 10.1002/1521-4141(200002)30:2<525::AID-IMMU525>3.0.CO;2-P |
| Citation | Johansson MH, et al. (2000) Differential effects on T cell and NK cell development by tissue-specific expression of H-2D(d) transgene. Eur J Immunol 30(2):525-33 |
| abstractText | The effect of tissue-specific expression of the MHC class I molecule H-2D(d) on T cell and NK cell specificity was studied in transgenic mice expressing the H-2D(d) gene under the control of the mouse metallothionein-I promoter. MTD mice expressed high amounts of H-2D(d) in the liver, intestine and testis, but only minute amounts in the thymus, spleen and kidney. Zinc administration resulted in a 1.5- and 8.5-fold increase in H-2D(d) expression in the liver and the intestine, respectively, but did not affect expression in the other organs tested. T cell tolerance developed towards H-2D(d) in MTD mice, even in the absence of zinc. In contrast, NK cell-mediated natural resistance against lymphoma grafts was not seen in MTD mice, despite zinc administration. NK cells in MTD mice also failed to develop self tolerance to H-2D(d). The lack of functional effects did not result from inability of NK cells in MTD mice to interact with H-2D(d), as down-regulation of Ly49A receptor expression was observed on liver NK cells in MTD mice. Our data reveal a difference between T cells and NK cells in their requirements for MHC class I molecules in specificity development. |
