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Protein Coding Gene : Tcf20 transcription factor 20

Primary Identifier  MGI:108399 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  21411
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables DNA-binding transcription factor activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Phelan-McDermid syndrome and autism spectrum disorder. Orthologous to human TCF20 (transcription factor 20).
PHENOTYPE: Mice homozygous for a null allele exhibit 80% lethality by P14, growth retardation, impaired neurogenesis, and decreased vocalization. Heterozygous mice show repetitive behaviors, social interaction defects, impaired working memory, and increased anxiety and vocalization. [provided by MGI curators]
  • synonyms:
  • 2810438H08Rik,
  • RIKEN cDNA 2810438H08 gene,
  • stromelysin 1 PDGF responsive element binding protein,
  • MGI:1924331,
  • Tcf20,
  • MGD-MRK-37441,
  • transcription factor 20,
  • SPBP,
  • mKIAA0292

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For