Primary Identifier | MGI:107562 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 74100 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Predicted to enable calmodulin binding activity and nucleic acid binding activity. Acts upstream of or within cellular response to heat. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; limb segment; sensory organ; and tail. Orthologous to human ARPP21 (cAMP regulated phosphoprotein 21). PHENOTYPE: Homozygous null mice are viable and display normal brain anatomy and no obvious behavioral or morphological defects. However, in medium spiny neurons from mutant mice, the ability of both M1 and D2 receptor activation to modulate L-type calcium channel currents is enhanced by nearly 2-fold. [provided by MGI curators] |