| First Author | Lambert J | Year | 1999 |
| Journal | Virology | Volume | 264 |
| Issue | 1 | Pages | 181-6 |
| PubMed ID | 10544143 | Mgi Jnum | J:58403 |
| Mgi Id | MGI:1347631 | Doi | 10.1006/viro.1999.9992 |
| Citation | Lambert J, et al. (1999) Identification of a common site of provirus integration in radiation leukemia virus-induced T-cell lymphomas in mice. Virology 264(1):181-6 |
| abstractText | The BL/VL(3) Kaplan radiation leukemia virus (RadLV-VL(3)) is a nondefective retrovirus that induces T cell lymphomas in several strains of mice. By using DNA probes derived from RadLV/VL(3) provirus-flanking sequences cloned from the BL/VL(3) cell line, we identified a DNA region rearranged in 5 of 19 tumors analysed (25%). All proviruses were integrated in the same 5'-to-3' orientation in a small DNA region called Kis1 (Kaplan integration site 1). This region was localized on distal mouse chromosome 2 in a region not previously identified as important to lymphomagenesis. The cells rearranged at the Kis1 locus represent a clonal subpopulation of the clonal tumor masses examined, indicating a probable role of Kis1 in tumor progression. Copyright 1999 Academic Press. |
