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Protein Coding Gene : Tns1 tensin 1

Primary Identifier  MGI:104552 Organism  Mus musculus
Chromosome  1 NCBI Gene Number  21961
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 5.3.0)

Predicted to enable actin binding activity. Acts upstream of or within cell-substrate junction assembly and fibroblast migration. Located in focal adhesion. Is expressed in several structures, including future midbrain; gut; metanephros; nasal process; and yolk sac. Orthologous to human TNS1 (tensin 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1200014E20 gene,
  • RIKEN cDNA E030018G17 gene,
  • 1110018I21Rik,
  • Tns1,
  • 1200014E20Rik,
  • MGI:1918975,
  • MGI:1915754,
  • RIKEN cDNA E030037J05 gene,
  • expressed sequence AI648117,
  • MGI:2138313,
  • E030018G17Rik,
  • E030037J05Rik,
  • AI648117,
  • MGI:2444104,
  • tensin 1,
  • MGD-MRK-25984,
  • Tns,
  • tensin,
  • RIKEN cDNA 1110018I21 gene

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

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540 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications