| Primary Identifier | MGI:99569 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 14739 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). PHENOTYPE: Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
