| First Author | Hasegawa S | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 186 |
| Issue | 1-2 | Pages | 75-85 |
| PubMed ID | 17428546 | Mgi Jnum | J:150626 |
| Mgi Id | MGI:3851085 | Doi | 10.1016/j.jneuroim.2007.03.005 |
| Citation | Hasegawa S, et al. (2007) Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. J Neuroimmunol 186(1-2):75-85 |
| abstractText | Microglia participate in immune responses in the brain. However, little is known about the contact-mediated interaction between microglia and neurons. We report here that the cell-to-cell contacts between microglial processes and dendrites of hippocampal CA1 neurons were dramatically increased in density and area following local injection of kainic acid (KA). A similar KA-induced increase in the degree of intercellular contacts was observed in mice lacking telencephalin (TLCN), a neuronal dendritic adhesion molecule of ICAM family. The results suggest that adhesive contacts independent of TLCN and contact-mediated interactions between microglia and dendrites were promoted by excitotoxic brain injury. |
