| Type | MGI:General | Description | LCMV-infected mice develop clinical features of hemophagocytic lymphohistiocytosis including weight loss, body temperature drop, hunched posture, lethargy, pancytopenia, lack of neutrophilia, increased circulating aspartate transaminase level, increased circulating lactate dehydrogenase level, increased serum levels of IFN-gamma, IL1b, TNF-alpha and IL6, increased viral load and worsening condition compared with wild-type mice LCMV-infected mice develop more severe hemophagocytic lymphohistiocytosis than in Rab27aash and Prf1tm1Sdz homozygotes despite similar viral loads |
