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Allele : Hexa<tm1Grv> hexosaminidase A; targeted mutation 1, Roy A Gravel

Primary Identifier  MGI:2429698 Allele Type  Targeted
Attribute String  Null/knockout Gene  Hexa
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 11 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis of homozygous mutant mice showed an absence of normal transcript and the presence of an elongated transcript which contained neo sequence. Hydrolysis of 4-MUG-6-sulfate (MUGS) was reduced to less than 5% in homozygous mutant mice.
  • mutations:
  • Insertion
  • synonyms:
  • Hexa -,
  • Hexa -
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

15 Publication categories

Trail: Allele