| First Author | Vogt TK | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 17 | Pages | 3961-8 |
| PubMed ID | 19246338 | Mgi Jnum | J:148420 |
| Mgi Id | MGI:3844773 | Doi | 10.1182/blood-2008-08-176321 |
| Citation | Vogt TK, et al. (2009) Novel function for interleukin-7 in dendritic cell development. Blood 113(17):3961-8 |
| abstractText | Interleukin-7 (IL-7) is crucial for the development of T and B lymphocytes from common lymphoid progenitors (CLPs) and for the maintenance of mature T lymphocytes. Its in vivo role for dendritic cells (DCs) has been poorly defined. Here, we investigated whether IL-7 is important for the development or maintenance of different DC types. Bone marrow-derived DCs expressed the IL-7 receptor (IL-7R) and survived significantly longer in the presence of IL-7. Migratory DCs (migDCs) isolated from lymph nodes also expressed IL-7R. Surprisingly, IL-7R was not required for their maintenance but indirectly for their development. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) resident in lymph nodes and spleen were IL-7R(-). Using mixed bone marrow chimeras, we observed an intrinsic requirement for IL-7R signals in their development. As the number of CLPs but not myeloid progenitors was reduced in the absence of IL-7 signals, we propose that a large fraction of cDCs and pDCs derives from CLPs and shares not only the lymphoid origin but also the IL-7 requirement with lymphocyte precursors. |
