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Allele : Mdm2<tm2.1Ypz> transformed mouse 3T3 cell double minute 2; targeted mutation 2.1, Yanping Zhang
Primary Identifier  MGI:5649075 Allele Type  Targeted
Attribute String  Hypomorph Gene  Mdm2
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP site flanked neomycin resistance gene cassette was inserted into intron 11 and a tyrosine codon 487 (TAC) in exon 12 was changed to alanine (GCA) (p.Y487A). Cre-mediated recombination removed the neo cassette. This mutation disrupts the E3 ligase activity without altering binding to MDM4.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Mdm2<Y487A>,
  • Mdm2<Y487A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele

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Trail: Allele




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