| First Author | Chatani Y | Year | 1992 |
| Journal | Biochem Biophys Res Commun | Volume | 185 |
| Issue | 3 | Pages | 860-6 |
| PubMed ID | 1385703 | Mgi Jnum | J:1553 |
| Mgi Id | MGI:50080 | Doi | 10.1016/0006-291x(92)91706-v |
| Citation | Chatani Y, et al. (1992) Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes. Biochem Biophys Res Commun 185(3):860-6 |
| abstractText | We have examined the hepatocyte growth factor (HGF)-mediated changes in protein-tyrosine phosphorylation in mouse keratinocytes (PAM-212) and canine kidney epithelial cells (MDCK). In PAM-212 cells HGF and epidermal growth factor, both of which stimulated the DNA synthesis, rapidly induced the tyrosine phosphorylation of two 41-kDa and two 43-kDa proteins: increased tyrosine phosphorylation of those proteins has been commonly observed when quiescent fibroblasts are stimulated with a variety of mitogenic agents. In contrast, HGF did not stimulate the DNA synthesis but induced cell dissociation in MDCK cells; under this condition, increased tyrosine phosphorylation of the 41-kDa and 43-kDa protein was not observed. A possible role of the increased tyrosine phosphorylation of 41-kDa and 43-kDa protein in the signaling pathway of HGF is discussed. |
