| First Author | Kinnamon KE | Year | 1997 |
| Journal | Proc Soc Exp Biol Med | Volume | 216 |
| Issue | 3 | Pages | 424-8 |
| PubMed ID | 9402149 | Mgi Jnum | J:44622 |
| Mgi Id | MGI:1100643 | Doi | 10.3181/00379727-216-44192 |
| Citation | Kinnamon KE, et al. (1997) In pursuit of drugs for American trypanosomiasis: evaluation of some standards in a mouse model. Proc Soc Exp Biol Med 216(3):424-8 |
| abstractText | Forty-nine standard compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity. |
