Primary Identifier | MGI:4417969 | Allele Type | Transgenic |
Attribute String | Dominant negative, Inducible, Inserted expressed sequence | Gene | Tg(tetO-HDAC5*)1Eno |
Strain of Origin | (C57BL/6 x C3H)F1 | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This transgene consists of a FLAG-tagged version of human HDAC5 expressed from a tetracycline responsive promoter. In addition serine-to-alanine mutations, at residues 259 and 498, were created to prevent the export of the protein to the cytosol. This transgene acts as a dominant-negative regulator of myocyte enhancer factor-2 signaling. |