| Primary Identifier | MGI:1920722 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 73472 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable identical protein binding activity. Predicted to be involved in DNA damage response; mitochondrial protein catabolic process; and mitophagy by internal vacuole formation. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in mitochondrion and sperm flagellum. Predicted to be active in mitochondrial outer membrane. Orthologous to human SPATA18 (spermatogenesis associated 18). PHENOTYPE: Homo- or heterozygous KO in mice also carrying one copy of the ApcMin allele leads to increased intestinal adenoma and adenocarcinoma tumor incidence and size. This double mutation and homozygous KO of the gene alone results in lower internal mitochondrial cristae density in small intestinal mucosal epithelium. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
