First Author | Frentzel S | Year | 1992 |
Journal | FEBS Lett | Volume | 302 |
Issue | 2 | Pages | 121-5 |
PubMed ID | 1633842 | Mgi Jnum | J:954 |
Mgi Id | MGI:49486 | Doi | 10.1016/0014-5793(92)80420-l |
Citation | Frentzel S, et al. (1992) Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA. FEBS Lett 302(2):121-5 |
abstractText | We have cloned and analysed the second mouse MHC-linked proteasome subunit, designated MC13, which appears to be homologous to the human RING10 proteasome protein. The isolated cDNA has an ORF encoding a protein of 276 amino acids with a molecular weight of ca. 30 kDa. Sequence alignment reveals that the subunit MC13 and several other mammalian proteasome subunits are encoded by a second proteasome gene family. This second gene family encodes subunits of the beta-type, reveals striking sequence similarities with the beta-subunit of archaebacterial proteasomes and is related to, but distinct from, the genes encoding the so-called alpha-type subunits. |