| Primary Identifier | IPR035478 | Type | Domain |
| Short Name | SH3PXD2B_SH3_2 |
| description | This entry represents the second SH3 domain of SH3PXD2B.SH3 and PX domain-containing protein 2B (SH3PXD2B, also known as Fad49 or Tks4) is an adaptor protein required for functional podosome formation []. It binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides []. It regulates epidermal growth factor-dependent cell migration []and has been linked to cancer []. Mutations in the SH3PXD2B gene cause Frank-ter Haar syndrome, a rare disease characterised by abnormalities that affect bone, heart, and eye development []. It contains an N-terminal Phox homology (PX) domain and four SH3 domains. |
