Primary Identifier | MGI:108563 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 19261 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of I-kappaB phosphorylation; negative regulation of MAPK cascade; and negative regulation of cytokine production. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Located in plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to human SIRPA (signal regulatory protein alpha). PHENOTYPE: Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration. [provided by MGI curators] |