| Primary Identifier | MGI:2151253 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 12310 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcitonin receptor binding activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; and artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure. Located in cytoplasm; extracellular region; and terminal bouton. Is expressed in several structures, including genitourinary system; gut; lung; nasal cavity; and nervous system. Human ortholog(s) of this gene implicated in migraine and osteoporosis. Orthologous to several human genes including CALCA (calcitonin related polypeptide alpha). PHENOTYPE: Two separate peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Mice homozygous null for CGRP-alpha have changes in the vascular and nervous system. Mice lacking calcitonin have increased bone mineralization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
