| First Author | Huebner AK | Year | 2008 |
| Journal | Arch Biochem Biophys | Volume | 473 |
| Issue | 2 | Pages | 210-7 |
| PubMed ID | 18307972 | Mgi Jnum | J:135684 |
| Mgi Id | MGI:3794263 | Doi | 10.1016/j.abb.2008.02.013 |
| Citation | Huebner AK, et al. (2008) The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation. Arch Biochem Biophys 473(2):210-7 |
| abstractText | The Calca gene encodes two polypeptides, calcitonin (CT) and alpha-calcitonin gene-related peptide (alpha-CGRP), generated through alternative splicing. While CT, a hormone mainly produced by thyroidal C cells, has been described as a major regulator of bone resorption, alpha-CGRP, a neuropeptide expressed in the cells of the central and peripheral nervous system, is mostly known as a regulator of vascular tone. Surprisingly, the generation and skeletal analyses of two mouse deficiency models has recently uncovered a physiological function for both peptides in the regulation of bone formation. In the first model, where the replacement of exons 2-5 of the Calca gene resulted in the combined deficiency of CT and alpha-CGRP, an increased bone formation rate (BFR) was observed, whereas decreased BFR was found in the second model, where the introduction of a translational termination codon into exon 5 of the Calca gene resulted in the specific absence of alpha-CGRP. |
