| First Author | Byram SC | Year | 2003 |
| Journal | Brain Behav Immun | Volume | 17 |
| Issue | 6 | Pages | 417-25 |
| PubMed ID | 14583233 | Mgi Jnum | J:105947 |
| Mgi Id | MGI:3617056 | Doi | 10.1016/s0889-1591(03)00089-8 |
| Citation | Byram SC, et al. (2003) Natural killer cells do not mediate facial motoneuron survival after facial nerve transection. Brain Behav Immun 17(6):417-25 |
| abstractText | The goal of the current study was to determine if natural killer (NK) cells mediate facial motoneuron (FMN) survival following injury. Wild-type (WT), perforin/recombinase activating gene-2 knockout (pfp/RAG-2 KO), and common gamma-chain (gammac)/RAG-2 KO mice received a right facial nerve axotomy. In WT mice, FMN survival was 86+/-1.0% relative to the contralateral control side. In contrast, pfp/RAG-2 and gammac/RAG-2 KO mice exhibited significant decreases in FMN survival ( approximately 20% and approximately 30%, respectively), relative to WT. Reconstitution of pfp/RAG-2 and gammac/RAG-2 KO mice with normal NK cells alone, failed to restore FMN survival levels to those of WT, but did restore functional lytic activity against YAC-1 cells. Reconstitution of pfp/RAG-2 and gammac/RAG-2 KO mice with splenocytes, and pfp/RAG-2 KO mice with CD4+ T-lymphocytes alone or in combination with NK cells, restored FMN survival levels to those of WT. Thus, NK cells appear to not be a component of immune cell-mediated rescue of motoneurons from axotomy induced cell death. |
