| First Author | Dycaico MJ | Year | 1989 |
| Journal | Mol Biol Med | Volume | 6 |
| Issue | 2 | Pages | 137-41 |
| PubMed ID | 2615643 | Mgi Jnum | J:96760 |
| Mgi Id | MGI:3531387 | Citation | Dycaico MJ, et al. (1989) Neonatal growth delay in alpha-1-antitrypsin disease. Influence of genetic background. Mol Biol Med 6(2):137-41 |
| abstractText | We have developed a transgenic mouse strain, Z#2, which represents a model for alpha 1-protease inhibitor (alpha 1-antitrypsin: alpha 1-Pi)-associated liver disease (Dycaico et al., 1988). Fifteen percent of human infants with alpha 1-Pi disease develop non-viral hepatitis which is sometimes associated with growth retardation. Such hepatitis and growth retardation tend to occur in a subset of families with other alpha 1-Pi affected members who have had non-viral hepatitis. The Z#2 mouse strain exhibits non-viral hepatitis and growth retardation. This phenotype is more pronounced in transgenic offspring of crosses between Z#2 mice and DBA/2J inbred mice, and less pronounced in transgenic offspring of crosses between Z#2 and CBA/J inbred mice. Such phenotypic differences resemble the phenotypic differences seen in human families with alpha 1-Pi-associated liver disease. |
