| First Author | Fernandes-Freitas I | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 1703 |
| PubMed ID | 32015477 | Mgi Jnum | J:293053 |
| Mgi Id | MGI:6407269 | Doi | 10.1038/s41598-020-58788-9 |
| Citation | Fernandes-Freitas I, et al. (2020) Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1. Sci Rep 10(1):1703 |
| abstractText | The nuclear hormone receptor Dax1 functions during development as a testes-determining gene. However, the phenotype of male mice lacking Dax1 is strain-dependent due to the background-specific abundance of male-determining Sry gene-transcripts. We hypothesised that inter-individual variation in Sry mRNA-abundance would result in a spectrum of phenotypes even within-strain. We found that while all XY C57BL/6J mice lacking Dax1 presented as phenotypic females, there was a marked inter-individual variability in measures of fertility. Indeed, we report rare occasions where sex-reversed mice had measures of fertility comparable to those in control females. On two occasions, these sex-reversed XY mice were able to give birth to live offspring following mating to stud-males. As such, this work documents within-strain variability in phenotypes of XY mice lacking Dax1, and reports for the first time a complete sex-reversal capable of achieving live birth in these mice. |
