| Primary Identifier | MGI:2387586 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 209039 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including identical protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Acts upstream of or within several processes, including collagen metabolic process; multicellular organismal-level homeostasis; and response to muscle activity. Predicted to be located in anchoring junction; cytoplasm; and plasma membrane. Predicted to be active in focal adhesion. Is expressed in genitourinary system; hand mesenchyme; hindlimb digit mesenchyme; sensory organ; and skeleton. Used to study Pierson syndrome. Orthologous to human TNS2 (tensin 2). PHENOTYPE: Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
